|
KMID : 0620720100160040223
|
|
Natural Product Sciences
2010 Volume.16 No. 4 p.223 ~ p.227
|
|
|
DNA Topoisomerase 1 Inhibitory Activity of Stilbenes and Oligostilbenes from Leaf and Stem of Vitis amurensis
|
|
Kang Na-Na
Ha Do-Thi
Myung Pyung-Keun
Bae Ki-Hwan
Park Chang-Sik
|
|
|
Abstract
|
|
|
|
The DNA Topoisomerase I (DNA Topo I) inhibitory effect of ten isolated compounds (1-10) from the leaf and stem of Vitis amurensis were examined. Among them, amurensin G (5) and r-2-viniferin (7) showed high potent inhibitory activity against DNA Topo I. DNA Topo I, an important target for anticancer drugs, can cause DNA breaks and play a key role during cell proliferation, transcription and repair. Thus, the results suggest that the selected compounds (5 and 7) from Vitis amurensis have a possibility as DNA Topo I-targeting anticancer agents.
|
|
|
KEYWORD
|
|
|
Vitis amurensis, Stilbenes and Oligostilbenes, DNA Topo 1
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|