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KMID : 0620720100160040239
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Natural Product Sciences
2010 Volume.16 No. 4 p.239 ~ p.244
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Screening of Protein Tyrosine Phosphatase 1B Inhibitory Activity from Some Vietnamese Medicinal Plants
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Duc Manh Hoang
Lee Myoung-Sook
Trinh Nam Trung
Bae Ki-Hwan
Ha Do-Thi
Phan Thi Thu Hien
Hoang Van Luong
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Abstract
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Protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin signaling, has served as a potential drug target for the treatment of type 2 diabetes. The MeOH extracts of twenty-nine medicinal plants, traditionally used in Vietnam as anti-diabetes agents, were investigated for PTP1B inhibitory activity in vitro. The results indicated that, most materials showed moderate to strong inhibitory activity with IC50 values ranging from 3.4 μg/mL to 35.1 μg/mL; meanwhile, eleven extracts (37.9%) could demonstrate PTP1B activity with IC50 values less than 15.5 μg/mL; sixteen extracts (55.2%) could demonstrate PTP1B activity with IC50 values ranging from 15.5 μg/mL to 35.1 μg/mL. The study may provide a proof, at least in a part, for the ethno-medical use in diabetes disease of these plants.
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KEYWORD
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Vietnamese medicinal plants, Protein tyrosine Phosphatase 1B, PTP1B, diabetes
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