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KMID : 0620720100160040245
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Natural Product Sciences
2010 Volume.16 No. 4 p.245 ~ p.250
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The Inhibitory Effect of Bamboo Culm Extract on the Development of Pulmonary Inflammation in Pristane-Induced Lupus Mice
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Chae Byeong-Suk
Shin Tae-Yong
Kim Dae-Keun
Eun Jae-Soon
Kwon Gi-Sung
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Abstract
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Pulmonary pathogenesis in lupus is characterized by interstitial inflammation and vasculitis in lungs. We investigated whether bamboo culm extract (BC) attenuates pulmonary inflammation and lung injury in pristane-induced lupus mice. The pristane-induced lupus mice and healthy mice were administrated with BC 0.5 ml/kg or PBS orally once a day for 14 days. Our results demonstrated that BC significantly attenuated levels of bronchoalveolar lavage (BAL) IL-6, IL-10, IFN-r, PGE2 and VEGF, and pulmonary vascular permeability in pristane-induced lupus mice. Therefore, these findings suggest that BC may inhibit development of pulmonary inflammation and lung injury in lupus.
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KEYWORD
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Bamboo culm, PGE2, Lupus, BAL proinflammatory cytokine, VEGF, pulmonary vascular permeability
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