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KMID : 0620720100160040287
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Natural Product Sciences
2010 Volume.16 No. 4 p.287 ~ p.294
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Screening of 50 Korean Herbal formulas with Inhibitory Effects on Acetylcholinesterase Activity and Amyloid-β Aggregation
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Lim Hye-Sun
Kim Yoon-Ju
Kim Ohn-Soon
Jeong Soo-Jin
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Abstract
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Acetylcholinesterase (AChE) activation and amyloid-β (Aβ) aggregation are major biological markers of Alzheimer’s disease. In the present study, we evaluated the inhibitory effects of 50 kinds of herbal formulas on AChE activity and Aβ aggregation. Among them, Hwanglyeonhaedok-tang, Cheonwangbosim-dan, Makmundong tang, and Gamisoyo-san had a potent effects on the inhbition of AChE activity. Sosiho-tang, Samsoeum, Cheonsimyeunjaeum, and Bunsimgieum exerted to have the inhibitory activity on Aβ aggregation. In addition, these 8 herbal formulas showed the -ethyl-benzothiazoline-6-sulfonic acid (ABTS) radical scavenging activity, indicating their antioxidant activities.
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KEYWORD
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Dementia, Acetylcholinesterase, Amyloid-β, Antioxidant, Herbal formula
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