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KMID : 0620720110170010010
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Natural Product Sciences
2011 Volume.17 No. 1 p.10 ~ p.13
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Cytotoxic Sesquiterpenoid from the Seeds of Amomum xanthioides
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Kim Ki-Hyun
Choi Jung-Wook
Lee Kang-Ro
Choi Sang-Un
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Abstract
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As parts of our continuing search for biologically active compounds from medicinal plants, we investigated the constituents of the seeds of Amomum xanthioides and isolated a sesquiterpenoid, a nerolidol derivative from its MeOH extract. The chemical structure was determined by spectroscopic methods, including 1D and 2D NMR to be (2S*,2`R*,5`S*)-2-(5`-ethenyltetrahydro-5`-methylfuran-2`-yl)-6-methylhept-5en-2-ol (1). Compound 1 was isolated for the first time from nature source. Compound 1 exhibited a good cytotoxicity against SK-OV-3 and SK-MEL-2 cells (IC50: 16.7 and 8.6 uM, respectively) using a SRB bioassay. In this study, we also determined the absolute configuration of 2 reported in previous paper.
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KEYWORD
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Amomum xanthioides, Zingiberaceae, Sesquiterpenoid, Cytotoxicity
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