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KMID : 0620720110170020085
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Natural Product Sciences
2011 Volume.17 No. 2 p.85 ~ p.89
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Cytotoxicity of Ergosterol Derivatives from the Fruiting Bodies of Hygrophorus russula
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Lee Ik-Soo
Kim Jin-Pyo
Bae Ki-Hwan
Na Min-Kyun
Jung Hyun-Ju
Min Byung-Sun
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Abstract
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Bioassay-guided fractionation of the CHCl3-soluble fraction of a MeOH extract of the fruiting bodies of Hygrophorus russula led to the isolation of five ergosterol derivatives (1-5). The structures of these compounds were identified as ergosterol peroxide (1), ergosta-4,6,8(14),22-tetraen-3-one (2), ergosta-7,22-diene-3B,5a,6a-triol (3), ergosta-7,22-diene-3B,5a,6B,9a-tetraol (4), and 5a,6a-epoxy-ergosta-8(14),22-diene-3B,7a-diol (5) by comparing their physicochemical and spectral data with those in the literature. These compounds were evaluated for in vitro cytotoxicity against A549 and XF498 cancer cell lines. Most of the tested compounds, except for compound 3, exhibited moderate cytotoxicity against both A549 and XF498 cell lines with IC50 values ranging from 10.2 to 18.3 ug/mL and from 11.4 to 24.6 ug/mL, respectively.
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KEYWORD
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Hygrophorus russula, Hygrophoraceae, Ergosterol derivatives, Cytotoxicity
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