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KMID : 0620720110170020090
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Natural Product Sciences
2011 Volume.17 No. 2 p.90 ~ p.94
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Anti-Inflammatory Activity of Compounds from the Whole Plant of Patrinia saniculaefolia
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An Ren-Bo
Na Min-Kyun
Chang Hyeun-Wook
Min Byung-Sun
Bae Ki-Hwan
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Abstract
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An in vitro bioassay-guide revealed that the methanol (MeOH) extract of the whole plant of Patrinia saniculaefolia (Valerianaceae) showed cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) dual inhibitory activity by assessing their effects on the production of prostaglandin D2 (PGD2) and leukotriene C4 (LTC4) in mouse bone marrow-derived mast cells (BMMCs). Phytochemical study of the MeOH extract of this plant led to the isolation of twelve compounds; B-farnesene (1), squalene (2), nardostachin (3), patridoid I (4), patridoid II (5), patridoid II-A (6), oleanolic acid (7), oleanonic acid (8), 23-hydroxyursolic acid (9), oleanolic acid 3-O-a-L-arabinopyranoside (10), oleanolic acid 3-O-B-D-glucopyranoside (11), oleanolic acid 3-O-[B-D-xylopyranosyl-(1→3)-B-D-(6-O-butyl)glucuronopyranoside] (12). Among the compounds, 4 and 5 strongly inhibited both the COX-2-dependent PGD2 generation with IC50 values of 8.7 and 13.6 uM, respectively, and the generation of LTC4 in the 5-LOX dependent phase with IC50 values of 41.7 and 46.9 uM, respectively, which suggest that the anti-inflammatory activity of P. saniculaefolia might occur in part via the inhibition of both PGD2 and LTC4 generation by 4 and 5.
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KEYWORD
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Patrinia saniculaefolia, Valerianaceae, Cyclooxygenase-2, 5-Lipoxygenase, Anti-inflammatory activity
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