|
KMID : 0620720110170020100
|
|
Natural Product Sciences
2011 Volume.17 No. 2 p.100 ~ p.103
|
|
|
Cytotoxic Activity of Parthenin, a Sesquiterpene Isolated from a Crinum ensifolium
|
|
Nguyen Minh Khoi
Phuong Thien Thuong
Dat Nguyen-Tien
Na Min-Kyun
Min Byung-Sun
Bae Ki-Hwan
|
|
|
Abstract
|
|
|
|
Phytochemical study on the ethanol extract of a Crinum species by bioassay-guided fractionation resulted in the isolation of an active principle, which was determined as parthenin (1) on the basis of physicochemical and spectroscopic analyses. This is the first report on the existence of a sesquiterpenoid from Crinum ensifolium. Compound 1 was found to show strong cytotoxic activity against some cancer cell lines and strongly inhibit NF-kB activity with the IC50 value of 1.82 uM.
|
|
|
KEYWORD
|
|
|
Crinum ensifolium, Amaryllidaceae, parthenin, cytotoxic activity, NF-kB inhibition
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|