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KMID : 0620720110170020108
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Natural Product Sciences
2011 Volume.17 No. 2 p.108 ~ p.112
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Cholinesterase Inhibitory Activities of Alkaloids from Corydalis Tuber
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Tran Manh Hung
Nguyen Trung Nhan
Nguyen Thi Thanh Mai
Tran Le Quan
Phuong Thien Thuong
Choi Jae-Sue
Woo Mi-Hee
Min Byung-Sun
Bae Ki-Hwan
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Abstract
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Several isoquinoline alkaloids (1-18), which have basic chemical structures as protoberberine and aporphine skeletones, were evaluated for their inhibitory activities on AChE and BuChE. Among them, compounds 3, 4, 6, 8 and 12 showed the potent AchE activity with the IC50 values ranging from 10.2±0.5 μM to 24.5±1.6 uM, meanwhile, compound 14-17 exhibited strong inhibitory activity with IC50 values from 2.1±0.2 to 5.5±0.3 uM. Compounds 14-17 exhibited selective inhibition for AChE compared with BuChE. The isoquinoline alkaloid possesses aromatic methylenedioxy groups and quaternary nitrogen atoms are crucial for the anti-cholinesterase inhibitory activity.
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KEYWORD
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Corydalis turtschaninovii, Papaveraceae, Isoquinoline alkaloids, Cholinesterase, Alzheimer`s disease, Structures and activity relationship
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