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KMID : 0620720110170021442
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Natural Product Sciences
2011 Volume.17 No. 2 p.1442 ~ p.146
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Superoxide Radical Scavengers from the Whole Plant of Veronica peregrina
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Ahn Dal-Rae
Yang Jae-Heon
Kim Dae-Keun
Lee Sa-Im
Cho Chong-Hyeon
Hwang Yong-Hun
Park Jong-Han
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Abstract
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In the course of screening for antioxidant compounds by measuring the radical scavenging effect on 1,1-diphenyl- 2-picrylhydrazyl (DPPH), a total extract from the whole plant of Veronica peregrina (Scrophulariaceae) was found to show potent antioxidant activity. Subsequent activity-guided fractionation of the methanolic extract led to the isolation of six phenolic compounds including chrysoeriol (1), diosmetin (2), 4- hydroxybenzoic acid (3), apigenin (4), caffeic acid methylester (5) and protocatechuic acid (6). Their structures were elucidated by spectroscopic studies. Compounds 1-5 were isolated for the first time from this plant. Compounds 5 and 6 showed significant antioxidative effects in DPPH free radical scavenging and superoxide quenching activity assays.
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KEYWORD
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Veronica peregrina, Scrophulariaceae, phenolic compounds, DPPH, superoxide quenching activity
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