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KMID : 0620720110170030216
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Natural Product Sciences
2011 Volume.17 No. 3 p.216 ~ p.220
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Maslinic Acid, a Triterpenoid from the Root Barks of Ulmus davidiana var. japonica, Affects the Viability of HSC-T6 Hepatic Stellate Cells
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Lee Sang-Hoon
Qing Liu
Kim Seon-Beom
Ahn Jong-Hoon
Hwang Bang-Yeon
Lee Mi-Kyeong
Ahn Mi-Jeong
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Abstract
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Activation of hepatic stellate cells (HSCs) characterized by increased proliferation and extracellular matrix deposition is identified as the major pathological feature of hepatic cirrhosis. Therefore, suppression of HSC activation has been proposed as an important antifibrotic therapeutic strategy. In the present study, we investigated the antiproliferative activity of root barks of Ulmus davidiana var. japonica (Ulmaceae) by employing HSC-T6 hepatic stellate cells as an in vitro assay system. Further investigation of the n-hexane and CHCl3 fractions of root barks of U. davidiana var japonica led to the isolation of six triterpenoids: friedelin (1), epifridelanol (2), oleanolic acid (3), maslinic acid (4), B-amyrin (5) and a-amyrin (6), together with B-sitosterol (7) and daucosterol (8). Among these compounds, 2, 3 and 4 significantly inhibited HSC proliferation. In addition, 4 inhibited HSC proliferation in time- and concentration-related manners, via a partially direct toxic effect, as assessed by morphological changes and release of lactate dehydrogenase.
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KEYWORD
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Ulmus davidiana var. japonica, Ulmaceae, maslinic acid, antifibrotic, HSC-T6, hepatic stellate cells, triterpenoid
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