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KMID : 0620720110170030221
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Natural Product Sciences
2011 Volume.17 No. 3 p.221 ~ p.224
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Neuroprotective Compounds Isolated from the Methanolic Extract of Lonicera japonica
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Weon Jin-Bae
Yang Hye-Jin
Lee Bo-hyoung
Yun Bo-Ra
Ma Choong-Je
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Abstract
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A CH3Cl extract from the flower of Lonicera japonica (Lauraceae) significantly protected primary cultures of rat cortical cells injured by the excitotoxic amino acid, L-glutamate. Loganin (1), secoxyloganin (2), caffeic acid (3) rutin (4), hyperoside (5), quercetin-3-O-glucoside (6), lonicerin (7), kaempferol-3-O-rutinoside (8), luteolin-7-O-b-D-glucopyranoside (9), quercetin (10) and luteolin (11) were isolated by bioactivity-guided fractionation from the CH3Cl fraction and further separated using chromatographic techniques. Caffeic acid, lonicerin, kaempferol-3-O-rutinoside, quercetin and luteolin had significant neuroprotective activities against glutamate-induced neurotoxicity in primary cultures of rat cortical cells at concentrations ranging from 0.1uM to 10.0 uM.
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KEYWORD
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Lonicera japonica, neuroprotection, Lonicerin, glutamate neurotoxicity
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