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KMID : 0620720110170030230
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Natural Product Sciences
2011 Volume.17 No. 3 p.230 ~ p.233
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Inhibition of Aldose Reductase on Rat Lens by Tartary Buckwheat
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Mok So-Youn
Lee Jeong-Min
Kim Hye-Min
Lee Dong-Gu
Lee Sang-Hyun
Yoon Young-Ho
Cho Eun-Ju
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Abstract
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To evaluate the potential of naturally occurring aldose reductase (AR) inhibitors from food material, MeOH extract and stepwise polarity fractions from tartary buckwheat and two common Korean buckwheat cultivars, yangjul-maemil and daesan-maemil, were tested on AR inhibition in rat lens in vitro. The EtOAc fraction from tartary buckwheat exhibited good AR inhibitory activity (IC50 value, 8.19 ug/ml). A portion of the EtOAc fraction from tartary buckwheat led to the isolation of rutin by MeOH recrystalization. Rutin exhibited good AR inhibitory activity (IC50 value, 9.28 uM). These results suggest that tartary buckwheat could be a useful food material in the development of a novel AR inhibitory agent against diabetic complications.
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KEYWORD
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Aldose reductase, diabetic complications, rutin, tartary buckwheat
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