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KMID : 0620720110170040363
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Natural Product Sciences
2011 Volume.17 No. 4 p.363 ~ p.366
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Analysis of the Components of Guibitang and Fermented Guibi-tang and their Ability to Inhibit Angiotensin-converting Enzyme
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Chun Liang
Yun Na-Young
Jung Sang-Won
Kim Dong-Seon
Ma Jin-Yeul
Lee Young-Jae
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Abstract
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Guibi-tang is a traditional medicine used for the treatment of colds. We investigated the levels of several compounds in Guibi-tang before and after fermentation with Lactobacillus and tested their ability to inhibit angiotensin-converting enzyme. Six known compounds (decursin, decursinol angelate, nodakenin, liquiritin, formononetin, and 6-gingerol) and 2 unidentified compounds were detected in Guibi-tang (GB) and fermented Guibi-tang (FGB) by an established HPLC-DAD method. The levels of the 6 known compounds were decreased after fermentation. FGB showed more potent inhibition of angiotensin-converting enzyme activity than GB. In conclusion, fermentation with Lactobacillus affects the content of several compounds in GB and improves its angiotensin-converting enzyme inhibitory activity.
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KEYWORD
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Guibi-tang, fermentation, angiotensin-converting enzyme
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