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KMID : 0620720120180010001
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Natural Product Sciences
2012 Volume.18 No. 1 p.1 ~ p.7
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Study on DPPH Free Radical Scavenging and Lipid Peroxidation Inhibitory Activities of Vietnamese Medicinal Plants
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Phan Thi Anh Dao
Nguyen Xuan Hai
Nguyen Trung Nhan
Tran Le Quan
Nguyen Thi Thanh Mai
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Abstract
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Among 90 Vietnamese medicinal plant extracts investigated for their antioxidant activity by DPPH assay at various concentrations from 10 - 100 ug/mL, 67 showed an inhibition rate over 50% at 100 ug/mL; 47 had greater than 50% inhibition at 50 ug/mL; 17 showed over 50% inhibition at 25 ug/mL. 8 extracts which exhibited strong inhibitory activity more than 50% inhibition at 10 ug /mL were further tested for lipid peroxidation inhibition by TBA assay. They displayed activity with IC50 values from 30.6 to 158.9 ug/mL, Until now, this is the first report on antioxidant activity of the female flower of Borassus flabellifer, and the stem of Combretum latifolium, Embelia ribes, Spatholobus parviflorus, and Tetrastigma erubescens. Fractionations of the EtOAc extract prepared from S. parviflorus led to the isolation of protocatechuic acid (1), ferulic acid (2), epicatechin (3), and gallic acid (4). These compounds showed significant DPPH inhibitory activity with IC50 values from 6.5 to 23.6 uM.
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KEYWORD
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Vietnamese medicinal plant, Antioxidant activity, DPPH, Lipid peroxidation, Spatholobus parviflorus
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