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KMID : 0620720120180010047
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Natural Product Sciences
2012 Volume.18 No. 1 p.47 ~ p.51
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Screening of a-Glucosidase Inhibitory Activity of Vietnamese Medicinal Plants: Isolation of Active Principles from Oroxylum indicum
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Mai Thanh Thi Nguyen
Nhan Trung Nguyen
Hai Xuan Nguyen
Thuy Nghiem Ngoc Huynh
Min Byung-Sun
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Abstract
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Among 38 Vietnamese medicinal plant extracts investigated for their a-glucosidase inhibitory activity, 35 extracts showed IC50 values below 250 ug/mL, The MeOH extracts of the heartwood of Oroxylum indicum, the seeds of Caesalpinia sappan, and the fruits of Xanthium strumarium exhibited strong α-glucosidase inhibitory activity with IC50 values less than 50 ug/mL. Fractionation of the MeOH extract of the heartwood of O. indicum led to the isolation of oroxylin A (1), oroxyloside (2), hispidulin (3), apigenin (4), ficusal (5), balanophonin (6), 2-(1-hydroxymethylethyl)-4H,9H-naphtho[2,3-b]furan-4,9-dione (7), salicylic acid (8), p-hydroxybenzoic acid (9), protocatechuic acid (10), isovanillin (11), and β-hydroxypropiovanillon (12), Compounds 1 - 3, 5, 6, 8, 10, and 12 showed more potent activities, with IC50 values ranging from 2.13 to 133.51 uM, than a positive control acabose (IC50, 241.85 uM). The kinetic study indicated that oroxyloside (2) displayed mixed-type inhibition with inhibition constant (Ki) was 3.56 uM.
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KEYWORD
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Vietnamese medicinal plants, a-glucosidase inhibitory activity, Oroxylum indicum
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