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KMID : 0620720120180020089
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Natural Product Sciences
2012 Volume.18 No. 2 p.89 ~ p.96
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Inhibitory Effect of Ligularia Stenocephala on the Cancer Metastasis
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Lee Dong-Keon
Kim Jin-Kyu
Kim Jong-Soo
Park Kyoung-Jae
Cha Dong-Seok
Jeon Hoon
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Abstract
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Ligularia stenocephala has been used as a traditional medicine for the treatment of asthma, arthritis, jaundice, and hyperpiesia. In this study, we investigated the anti-metastatic and hypnotic effects of the methanolic extract of L. stenocephala (MLS). Gelatin zymographic analysis revealed that MLS suppresses matrix metalloproteinase-2 (MMP-2) and MMP-9 activities in B16F10 cells. The gene expressions of MMPs were also down-regulated by MLS treatment in a dose-dependent manner. In addition, cancer cell invasion and migration were attenuated by MLS via suppression of NF-κB activation. The in vivo lung metastasis of B16F10 melanoma cells was also inhibited by the treatment of MLS. These findings show that MLS has anti-metastatic properties, and, therefore, it might be applicable as a valuable anti-metastatic agent.
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KEYWORD
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Ligularia stenocephala, Metastasis, Invasion, MMP
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