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KMID : 0620720120180020097
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Natural Product Sciences
2012 Volume.18 No. 2 p.97 ~ p.101
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Compounds from the Seeds of Myristica fragrans and Their Cytotoxic Activity
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To Dao Cuong
Lim Chae-Jin
Tran Thi Thu Trang
Bae Yoon-Ho
Nguyen Van Thu
Nguyen The Tung
Woo Mi-Hee
Min Byung-Sun
Tran Manh Hung
Choi Jae-Sue
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Abstract
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Six lignan compounds, 1-(17,21-dihydroxyphenyl)-9-(12,13-dihydroxyphenyl)-1-nonanone (malabaricone C) (1), 7`-(3`,4`-methylenedioxyphenyl)-8,8`-dimethyl-7-(3,4-dihydroxyphenyl)-butane (2), 7`-(3`,4`-dimethoxyphenyl)- 8,8`-dimethyl-7-(3-methoxy-4-hydroxyphenyl)-butane (3), 7-(4-hydroxy-3-methoxyphenyl)-7′-(3′,4′-methylenedioxyphenyl)- 8,8′-lignan-7-methyl ether (4), (+)-erythro-(7S,8R)-△8′ -7-hydroxy-3,4,3′,5′-tetramethoxy-8-O-4′-neolignan (5), and (+)- erythro-(7S,8R)-△8′ -7-acetoxy-3,4,3′,5′-tetramethoxy-8-O-4′-neolignan (6), were isolated from the seeds of Myristica fragrans. The chemical structures of these compounds were determined on the basis of spectroscopic analyses including 2D NMR. Compounds 1 - 6 were evaluated for their cytotoxic activity against the HL-60, MCF-7, and A549 cancer cell lines in in vitro.
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KEYWORD
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Myristica fragrans, Myristicaceae, Lignan, Cytotoxic activity
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