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KMID : 0620720120180020102
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Natural Product Sciences
2012 Volume.18 No. 2 p.102 ~ p.105
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Evaluation of u-Calpain Inhibitory Activity of Korean Indigenous Marine Organism Extracts
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Lee Yoo-Jin
Lee Eun-Young
Han Ah-Reum
Kwon Young-Joo
Seo Eun-Kyoung
Song Jun-Im
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Abstract
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Marine organism extracts were prepared from 26 species of Korean indigenous marine organisms, including 25 species belonging in class Anthozoa of phylum Cnidaria and a species belonging to subphylum Urochordata of phylum Chordata, and screened their inhibitory effects against u-calpain. As a result, the thirteen extracts were found to be active in the criteria of IC50 < 100 μg/mL. Among them, the MeOH extracts of Plexauroides praelonga and Alveopora japonica showed remarkable u-calpain inhibitory activity with IC50 values of 4.62 ± 0.22 and 4.82 ± 0.07 ug/mL, respectively. In addition, chemical investigation of A. japonica led to the isolation of an active compound, hexadecyl tetradecanoate, as a selective cathepsin B inhibitor (IC50 = 9.05 ± 2.45 uM). This compound was isolated as constituent of A. japonica for the first time in the present study.
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KEYWORD
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Korean indigenous marine organism, coral, Alveopora japonica, hexadecyl tetradecanoate, u-calpain, cathepsin B
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