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KMID : 0620720120180020111
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Natural Product Sciences
2012 Volume.18 No. 2 p.111 ~ p.115
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Radical Scavenging Constituents of Cyperus flaccidus
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Ahn Dal-Rae
Lee Hyun-jin
Ming Ming Xing
Chao Tao
Lee Eun-Byeol
Lee Tae-Gwan
Shin Tae-Yong
Eun Jae-Soon
Jeon Hoon
Lim Jong-Pil
Kim Dae-Keun
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Abstract
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In the course of screening for antioxidant compounds by measuring the DPPH (1,1-diphenyl-2- picrylhydrazyl) radical scavenging effect and superoxide quenching activity, methanol extract of Cyperus flaccidus (Cyperaceae) was found to show potent antioxidant activities. Subsequent activity-guided fractionation of the methanolic extract led to the isolation of ten compounds, kaempferol-3,7-O-α-L-dirhamnopyranoside (1), caffeic acid (2), quercetin-3-O-α-L-rhamnopyranosyl(1→6)-β-D-glucopyranoside (3), kaempferol-3-O-α-Lrhamnopyranoside (4), quercetin-3-O-α-L-rhamnopyranoside (5), luteoiln-7-O-β-D-glucopyranoside (6), kaempferol- 3-O-α-L-rhamnopyranosyl(1→6)-β-D-glucopyranoside (7), luteoiln (8), quercetin (9) and quercetin-3-O-β-Dglucuronide (10). Their structures were elucidated by spectroscopic studies. Compounds 1 - 10 were isolated for the first time from this plant. Among them, compounds 2, 8 and 9 showed the significant radical scavenging effects on DPPH, and the potent xanthine-originated superoxide quenching activities.
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KEYWORD
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Cyperus flaccidus, Cyperaceae, DPPH, Superoxide quenching activity
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