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KMID : 0620720120180030190
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Natural Product Sciences
2012 Volume.18 No. 3 p.190 ~ p.194
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Effects of Extract and Isorhamnetin Glycoside from Brassica juncea on Hepatic Alcohol-Metabolizing Enzyme System in Rats
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Hur Jong-Moon
Park Sang-Hyun
Park Jong-Cheol
Choi Jong-Won
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Abstract
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The effects of methanol extract of the leaves of Brassica juncea and its major component, isorhamnetin 3-O-B-D-glucopyranoside on hepatic alcohol metabolizing enzymes were investigated. The methanol extract and isorhamnetin 3-O-B-D-glucopyranoside supplementations increased the activities of microsomal ethanol oxidizing system and aldehyde dehydrogenase in a dose-dependent manner, and had mild effects on the activities of alcohol dehydrogenase and catalase. Isorhamnetin 3-O-B-D-glucopyranoside alleviated the adverse effect of ethanol ingestion by enhancing the activities of alcohol oxidizing emzymes, microsomal ethanol oxidizing system and aldehyde dehydrogenase.
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KEYWORD
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Alcohol detoxification, Isorhamnetin 3-O-B-D-glucopyranoside, Microsomal ethanol oxidizing system, Aldehyde dehydrogenase, Brassica juncea
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