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KMID : 0620720120180040211
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Natural Product Sciences
2012 Volume.18 No. 4 p.211 ~ p.214
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Extracellular Prostaglandin E2 Upregulation Effect of the Methanol Extract of Artemisia argyi
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Lee Kyoung-In
Moon Young-Sook
Choi Chul-Hee
Pyo Byoung-sik
Moon Young-Sook
Choi Chul-Hee
Pyo Byoung-sik
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Abstract
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Since 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is the key metabolic enzyme of prostaglandin E2 (PGE2), inhibition of 15-PGDH is supposed to facilitate various physiological functions by increasing PGE2. Methanol extract of Artemisia argyi (AAME) inhibited 15-PGDH (IC50: 13.13 ug/mL) with relatively low cytotoxicity (IC50: 415.00 ug/mL) and elevated extracellular PGE2 levels in HaCaT cells. Real-time PCR analysis showed that AAME decreased significantly mRNA expression of PG transporter (PGT) in HaCaT cells. These results indicate that AAME could be applicable to functional materials as a 15-PGDH inhibitor and PGT expression inhibitor for the upregulation of extracellular PGE2 level.
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KEYWORD
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Artemisia argyi, Prostaglandin E2, 15-Hydroxyprostaglandin dehydrogenase, Cyclooxygenases 1/2, Multidrug resistance-associated protein 4, PG transporter
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