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KMID : 0620720120180040233
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Natural Product Sciences
2012 Volume.18 No. 4 p.233 ~ p.238
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Cholinesterase Inhibitory Constituents from Capsosiphon fulvescens
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Zhe Fang
Jeong Su-Yang
Choi Jae-Sue
Min Byung-Sun
Min Bo-Kyung
Woo Mi-Hee
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Abstract
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Nine compounds (1 - 9), a-linolenic acid (1), cis-5,8,11,14,17-elcosapentaenoic acid (2), phytol (3), loliolide (4), uridine (5), thymidine (6), deoxyadenosine (7), adenine (8), and adenosine (9), were isolated from the n-hexane, methylene chloride, ethyl acetate and n-butanol fractions of Capsosiphon fulvescens. The structures of these compounds were elucidated on the basis of spectroscopic evidence. Compounds 1 - 9 exhibited acetylcholinesterase (AChE) inhibitory activities with IC50 values ranging from 114.91 to 252.40 ?M, whereas 2 - 4 showed butyrylcholinesterase (BChE) inhibitory activities with IC50 values ranging from 251.18 to 499.16 ?M.
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KEYWORD
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Capsosiphon fulvescens, DPPH, Acetylcholinesterase, Peroxynitrite, Butyrylcholinesterase
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