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KMID : 0620720120180040250
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Natural Product Sciences
2012 Volume.18 No. 4 p.250 ~ p.253
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Chemical Constituents from the Bark of Phellodendron amurense and Their Cytotoxic Effects on HL-60 Human Leukemia Cells
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Wei Li
Sun Ya-Nan
Xi Tao Yan
Yang Seo-Young
Choi Chun-Whan
Kim Eun-Ji
Kang Hee-Kyoung
Kim Young-Ho
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Abstract
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Phellodendri Cortex, phellodendron bark, has been used as a stomachic for intestinal function control and as an antimicro and anti-inflammatory agent. In this phytochemical study, eight compounds, berberine (1), palmatine (2), syringin (3), (+)-syringaresinol di-O-β-D-glucopyranoside (4), salvadoraside (5), citrusin B (6), osmanthuside H (7), and kelampayoside A (8), were isolated from the bark of Phellodendron amurense. Their structures were elucidated by comparing spectroscopic data with reported values. Compounds 1 - 8 were evaluated for cytotoxic activity against HL-60 human promyelocytic leukemia cells in vitro. Among them, compounds 1 and 2 reduced the viability of HL-60 cells significantly, with IC50 values of 26.0 and 18.5 ?M, respectively.
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KEYWORD
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Phellodendron amurense, Rutaceae, Cytotoxicity, HL-60 Leukemia cells
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