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KMID : 0620720120180040254
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Natural Product Sciences
2012 Volume.18 No. 4 p.254 ~ p.260
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Hesperidin Ameliorates TNF-a-Mediated Insulin Resistance in Differentiated 3T3-L1 Cells
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Chae Byeong-Suk
Shin Tae-Yong
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Abstract
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Adipose inflammation is linked to the development of insulin resistance and type 2 diabetes. Hesperidin (HES) is a flavonoid with antioxidant, anti-inflammatory and anti-diabetic properties. However, whether HES improves inflammation-mediated insulin resistance in adipose tissues remains unclear. The purpose of this study was to investigate whether HES attenuates inflammation-mediated insulin resistance in adipose tissue. Herein, RAW 264.7 cells and differentiated 3T3-L1 adipocytes were pretreated with various concentrations of HES in complete media for 1 h and then cultured in the presence or absence of LPS or TNF-a. Our results demonstrated that HES remarkably inhibited LPS-induced production of IL-6, TNF-a, and NO by RAW 264.7 cells in a dose-dependent manner. Also, HES inhibited TNF-a-induced production of IL-6 and PGE2 in differentiated 3T3-L1 cells, while upregulated TNF-a-suppressed expression of adiponectin and PPAR-r mRNA. These findings suggest that HES may ameliorate inflammation-mediated insulin resistance in adipose tissue.
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KEYWORD
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Hesperidin, IL-6, PGE2, Adiponectin, PPAR-r Insulin resistance, Adipocyte
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