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KMID : 0620720130190010001
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Natural Product Sciences
2013 Volume.19 No. 1 p.1 ~ p.7
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AMPK Activators from Natural Products: A Patent Review
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Mohammad Nasir Uddin
Govinda Sharma
Oh Won-Keun
Choi Hong-Seok
Lim Seong-Il
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Abstract
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AMP-activated protein kinase (AMPK) is a major cellular energy sensor and master regulator of metabolic homeostasis. On activation, this cellular fuel sensing enzyme induces a series of metabolic changes to balance energy consumption via multiple downstream signaling pathways controlling nutrient uptake and energy metabolism. This pivotal role of AMPK has led to the development of numerous AMPK activators which might be used as novel drug candidates in the treatment of AMPK related disorders, diabetes, obesity, and other metabolic diseases. Consequently, a number of patents have been published on AMPK activators from natural products and other sources. This review covers the patented AMPK activators from natural products and their therapeutic potential in treatment or prevention of metabolic diseases including diabetes and obesity.
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KEYWORD
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AMPK activators, Metabolic syndrome, Patents, Natural products
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