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KMID : 0620720130190010008
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Natural Product Sciences
2013 Volume.19 No. 1 p.8 ~ p.14
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Structure-Activity Relationship for Antidepressant Effect of Luteolin and Its Related Derivatives Isolated from Taraxacum mongolicum
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Hwang Keum-Hee
Kim Gun-Hee
Lee Nam-Kyung
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Abstract
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The inhibitory effect and the structure-activity relationships of luteolin and its related derivatives isolated from Taraxacum mongolicum against MAO activities were investigated. The activity-guided isolation of extract from Taraxacum mongolicum led to the isolation of three flavonoids, luteolin, diosmetin, and luteolin-7- glucoside, a polyphenol, chlorogenic acid, a tyrosine and a uridine. The inhibitory activities of luteolin and its related derivatives against MAOs activities are dependent on their molecular structures. The presence of the phenolic hydroxy group at para-position is the active site for MAO-A inhibition as well as of MAO-B. The methoxy group has no potential on MAO-A inhibition. An additional phenolic hydroxy group at the orthoposition alleviates about 4-fold MAO-A inhibitory activity of phenolic hydroxy group at para-position. A carboxylic group seems to be critical for DBH inhibition and has no effects on MAO.
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KEYWORD
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Taraxacum mongolicum, Monoamine oxidase inhibitor, Luteolin, Luteolin derivatives, Structureactivity relationship
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