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KMID : 0620720130190010066
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Natural Product Sciences
2013 Volume.19 No. 1 p.66 ~ p.70
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Cytotoxic and Anti-oxidant Constituents from the Aerial Parts of Aruncus dioicus var. kamtschaticus
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Bing Tian Zhao
Jeong Su-Yang
Viet Dung Vu
Min Byung-Sun
Woo Mi-Hee
Kim Young-Ho
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Abstract
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Ten compounds (1 - 10), palmitic acid (1), 10-nonacosanol (2), pentacosan-1-ol (3), phytol (4), B- sitosterol (5), B-sitosterol-3-O-B-D-glucopyranoside (6), 2,4-dihydroxycinnamic acid (7), hyperoside (8), uridine (9) and adenosine (10), were isolated from the n-hexane and EtOAc-soluble fractions of the aerial parts of A. dioicus var. kamtschaticus (Rosaceae). The structures of these compounds were elucidated on the basis of spectroscopic evidence. All compounds (1 - 10) were isolated for the first time from this plant. Cytotoxicity of 1 - 10 against Jurkat T (T-lymphocytic leukemia cells), HeLa (Human cervical epitheloid carcinoma cells), MCF-7 (Human breast cancer cells), and HL-60 (Human promyelocytic leukemia cells) cell lines was measured. Compound 6 showed good cytotoxicity against HL-60 cell line with IC50 value of 8.13 ug/mL. In addition, compounds 7 and 8 exhibited antioxidant activity with IC50 values of 16.30 and 12.42 ug/mL, respectively.
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KEYWORD
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Aruncus dioicus var. kamtschaticus, Rosaceae, Cytotoxicity
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