|
KMID : 0620720140200010017
|
|
Natural Product Sciences
2014 Volume.20 No. 1 p.17 ~ p.21
|
|
|
New Phytoformula (CAS) Containing the Roots of Cyathula officinalis, Achyranthes japonica and Sophora subprostrata Inhibits Collagen-induced Arthritis in Mice
|
|
Lee Jae-Hyung
Kim Hyun-Pyo
Lim Hyun
Kwon Yong-Soo
|
|
|
Abstract
|
|
|
|
The combined new phytoformula (CAS), a mixture (5 : 3 : 2, w/w/w) of the ethanol extracts of the roots of C. officinalis and A. japonica, and the n-butanol fraction of the S. subprostrata strongly inhibited arthritic severity score as well as IL-6 production in serum of collagen-induced arthritic mice. Histological observation also indicated that the CAS-treated group showed less breakdown of joint cartilage of the collagen-treated mice. In contrast, C. officinalis alone or a combination of A. japonica and S. subprostrata did not show significant inhibitory action on the same animal model. Thus, it is thought that CAS possesses a synergistic inhibitory action on arthritic condition. All these results strongly suggest that CAS may be a potential anti-arthritic agent.
|
|
|
KEYWORD
|
|
|
Arthritis, Cyathula officinalis, Achyranthes japonica, Sophora subprostrata, Inflammation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|