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KMID : 0620720140200020091
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Natural Product Sciences
2014 Volume.20 No. 2 p.91 ~ p.94
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Phytochemical Constituents of Bletilla striata and Their Cytotoxic Activity
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Woo Kyeong-Wan
Park Jong-Eel
Kim Ki-Hyun
Lee Kang-Ro
Choi Sang-Un
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Abstract
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Column chromatographic separation of the MeOH extract from the tubers of Bletilla striata yielded seven phenolic components including four phenanthrenes, 3,7-dihydroxy-2,4-dimethoxyphenanthrene (1), 3,7- dihydroxy-2,4,8-trimethoxyphenanthrene (2), 9,10-dihydro-4,7-dimethoxyphenanthrene-2,8-diol (3), and 9,10-dihydro- 1-(4`-hydroxybenzyl)-4,7-dimethoxyphenanthrene-2,8-diol (4) and three stilbenes, gigantol (5), 3`,4``-dihydroxy- 5`,3``,5``-trimethoxybibenzyl (6), and batatasin III (7). Their structures were determined on the basis of NMR spectroscopic data. Among them, compound 2, 3, and 6 were reported for the first time from this plant. The isolated compounds (1-7) were tested for cytotoxicity against four human tumor cell lines in vitro using a Sulforhodamin B bioassay.
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KEYWORD
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Bletilla striata, Orchidaceae, Stilbene, Phenanthrene, cytotoxicity
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