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KMID : 0620720140200020095
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Natural Product Sciences
2014 Volume.20 No. 2 p.95 ~ p.101
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Phytochemical Constituents of Salsola komarovii and Their Effects on NGF Induction
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Cho Hyeon-Kyung
Suh Won-Se
Kim Ki-Hyun
Lee Kang-Ro
Kim Sun-Yeou
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Abstract
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Five lignan glycosides, seven megastigmane glycosides, and seven phenolic compounds were isolated by repeated column chromatography from the MeOH extract of Salsola komarovii. Their structures were determined to be lariciresinol-9-O-β-D-glucopyranoside (1), alangilignoside C (2), conicaoside (3), (+)- lyoniresinol 9`-O-β-D-glucopyranoside (4), (8S,8`R,7`R)-9`-[(β-glucopyranosyl)oxy]lyoniresinol (5), blumenyl B β- D-glucopyranoside (6), blumenyl A β-D-glucopyranoside (7), staphylionoside D (8), icariside B2 (9), (6R,9S)-3- oxo-α-ionol β-D-glucopyranoside (10), 3-oxo-α-ionol 9-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (11), blumenol B 9-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (12), benzyl 6-O-β-D-apiofuranosyl-β-Dglucopyranoside (13), canthoside C (14), tachioside (15), isotachioside (16), biophenol 2 (17), 2-(3,4-dihydroxy)- phenyl-ethyl-β-D-glucopyranoside (18), and cuneataside C (19) by spectroscopic methods. All the isolated compounds 1 - 19 were reported from this source for the first time. Compounds 2, 3 and 6 upregulated NGF secretion to 118.8 ± 3.6%, 128.2 ± 9.3% and 111.1 ± 7.1% without significant cell toxicity.
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KEYWORD
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Salsola komarovii, Chemopodiaceae, NGF regulation, Lignan
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