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KMID : 0620720140200030137
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Natural Product Sciences
2014 Volume.20 No. 3 p.137 ~ p.145
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Biological Activities of Licorice F1 Lines and Content Analysis of Phytochemical Constituents
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Park Chun-Geon
Lee Jeong-Hoon
Lee Sang-Hoon
Choi Ae-Jin
Park Chung-Berm
Lee Ah-Young
Lee Jeong-Min
Park Jun-Yeon
Lee Sang-Hyun
Cho Eun-Ju
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Abstract
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The biological activities of licorice F1 (Glycyrrhiza glabra × G. uralensis) lines (G) were investigated, revealing strong radical scavenging activity targeting 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl (·OH) radicals. At a concentration of 100 μg/mL, most of the licorice F1 lines scavenged DPPH and ·OH by more than 80%. Gs-1, -2, and -6 can be considered good scavengers of DPPH radical and G-7 have higher antioxidant activity against ·OH radical. In addition, licorice F1 lines exerted effective anti-microbial activities against Escherichia coli (Gs-12, -17, and -18) and Staphylococcus aureus (Gs-3, -4, -5, -21, and -26). Moreover, Gs-2, - 20, -31, and -32 effectively inhibited the growth of Helicobacter pylori. Among licorice F1 lines, Gs-25 exhibited high anti-inflammatory effects on nitric oxide produced by lipopolysaccharide- and interferon-r-activated RAW 264.7 cells. Furthermore, Gs-1, -12, and -20 inhibited the growth of AGS human gastric adenocarcinoma cells by more than 60% at a concentration of 100 ug/mL and Gs-5, -11, -19, and -32 showed inhibitory effects against rat lens aldose reductase (IC50 values, 1.69, 6.07, 6.12, and 4.54 ug/mL, respectively). The total content of glycyrrhizin (1), glycyrrhetinic acid (2), glabridin (3), and isoliquiritigenin (4) in licorice F1 lines was high in Gs- 11, -15, and -30. The present study therefore indicated that Gs-2, -26, -31, and -32 of licorice F1 possessing strong anti-oxidative, anti-microbial, anti-inflammatory, anti-cancer, and aldose reductase inhibitory effects may be used as a possible source material for natural health supplements in the future.
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KEYWORD
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Licorice, Analysis, Bioassay, Industrial application, Medicinal plant
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