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KMID : 0620720140200030176
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Natural Product Sciences
2014 Volume.20 No. 3 p.176 ~ p.181
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Evaluation of the Antioxidant Activities of Natural Components of Artemisia iwayomogi
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Yan Xi-Tao
Yan Ding
Lee Sang-Hyun
Li Wei
Sun Ya-Nan
Yang Seo-Young
Jang Hae-Dong
Kim Young-Ho
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Abstract
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The antioxidant activities of 29 components isolated from the aerial parts of Artemisia iwayomogi were evaluated in vitro and in cell culture. Among the tested compounds, 2, 6, 8, 10, 13, and 14 exhibited the greatest peroxyl radical-scavenging activities in the oxygen radical absorbance capacity (ORAC) assay, and 2, 10, and 14 also showed significant reducing capacities. However, all compounds showed weak metal chelating activities. Their cellular antioxidant activities were evaluated in HepG2 cells. At 10 μM, compounds 6, 8, and 14 exhibited stronger protection against 2,2``-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress than compounds 2, 10, and 13. Moreover, Compounds 2 and 8 were more effective in protecting against Cu2+-induced oxidative stress than compounds 6, 10, 13, and 14 at 10 μM. These results suggest that the phenolic compounds in A. iwayomogi have the potential to be developed as natural antioxidants for the treatment of oxidative stress-related diseases.
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KEYWORD
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Artemisia iwayomogi, Compositae, Oxygen radical absorbance capacity, ORAC, Cellular antioxidant activity, HepG2 cell
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