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KMID : 0620720140200030202
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Natural Product Sciences
2014 Volume.20 No. 3 p.202 ~ p.205
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Antimicrobial Constituents from the Bacillus megaterium LC Isolated from Marine Sponge Haliclona oculata
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Pham Viet Cuong
Nguyen Thi Kim Cuc
Vu Thi Quyen
Pham Thanh Binh
Phan Van Kiem
Nguyen Hoai Nam
Nguyen Tien Dat
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Abstract
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Three compounds including 7,7-bis(3-indolyl)-p-cresol (1), cyclo-(S-Pro-R-Leu) (2) and cyclo-(S-Pro- R-Val) (3) were isolated from the strain of Bacillus megaterium LC derived from the marine sponge Haliclona oculata. All the isolated compounds showed antimicrobial activity at MIC values ranging from 0.005 to 5 μg/mL against Gram-negative bacteria Vibrio vulnificus and V. parahaemolyticus, gram-positive bacteria Bacillus cereus and Micrococcus luteus, and the dermatophyte Trichophyton mentagrophytes. The results suggested that these compounds might have potential to be developed as agents treating dermatosis and controlling vibriosis in aquaculture.
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KEYWORD
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Bacillus megaterium, Haliclona oculata, sponge-associated bacteria, antimicrobial
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