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KMID : 0620720140200040196
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Natural Product Sciences
2014 Volume.20 No. 4 p.196 ~ p.300
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Effects of (-)-Sesamin on Dopamine Biosynthesis in PC12 Cells
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Park Hyun-Jin
Lee Kyung-Sook
Ting Ting Zhao
Shin Keon-Sung
Park Keun-Hong
Lee Myung-Koo
Lee Seung-Ho
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Abstract
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The present study investigated the effects of (-)-sesamin on dopamine biosynthesis in PC12 cells. Treatment with (-)-sesamin (25 and 50 μM) increased intracellular dopamine levels and enhanced L-DOPAinduced increase in dopamine levels in PC12 cells. (-)-Sesamin (25 and 50 μM) also induced the phosphorylation of cyclic AMP-dependent kinase A (PKA), cyclic AMP-response element binding protein (CREB) and tyrosine hydroxylase (TH) in PC12 cells. These results suggest that (-)-sesamin induces dopamine biosynthesis via the PKA-CREB-TH pathways in PC12 cells. (-)-Sesamin needs to be studied further to serve as an adjuvant phytonutrient in neurodegenerative disease.
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KEYWORD
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(-)-Sesamin, Dopamine biosynthesis, PKA, CREB, Tyrosine hydroxylase, PC12 cells
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