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KMID : 0620720140200040237
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Natural Product Sciences
2014 Volume.20 No. 4 p.237 ~ p.242
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Protective Effect of Crataegus pinnatifida and Cinnamomum cassia on Ethanol-induced Cytotoxicity and DNA Damage in HepG2 Cells
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Kim Nam-Yee
Song Eun-Jeong
Heo Moon-Young
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Abstract
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Plant extracts produced from branches of Crataegus pinnatifida and barks of Crataegus pinnatifida inhibited ethanol-induced cytotoxicity and DNA damage in liver cells. Furthermore, these two extracts inhibited the expression and activities of CYP2E1 enzyme. Cinnamomum cassia had a better effect on inhibition of DNA damage than Crataegus pinnatifida, as well as showed a high tendency to inhibit CYP2E1 expression and catalytic activities. It is considered that extracts produced from Crataegus pinnatifida or Cinnamomum cassia have an effect to reduce ethanol-induced cytotoxicity and DNA damage in liver cells. Therefore, we suggest to use Crataegus pinnatifida and Cinnamomum cassia and their ingredients as potential candidate substances to prevent and treat ethanol-induced cytotoxicity and genotoxicity in liver cells.
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KEYWORD
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Ethanol, Cytotoxicity, Comet assay, DNA damage, Crataegus pinnatifida, Cinnamomum cassia, Plant extract
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