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KMID : 0620720140200040274
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Natural Product Sciences
2014 Volume.20 No. 4 p.274 ~ p.280
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Bioactive Constituents from the n-Butanolic Fraction of Aruncus dioicus var. kamtschaticus
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Quoc Hung Vo
Phi Hung Nguyen
Bing Tian Zhao
Yen Nguyen Thi
Duc Hung Nguyen
Kim Won-Il
Seo U-Min
Min Byung-Sun
Woo Mi-Hee
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Abstract
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Six compounds were isolated from the n-BuOH fraction of the aerial parts of Aruncus dioicus var. kamtschaticus including: sambunigrin (1), prunasin (2), aruncide A (3), aruncide C (4), 1-O-caffeoyl-β-Dglucopyranose (5), and caffeic acid (6). Their structures were confirmed by comparing the spectral data with those reported in the literature. The isolated compounds (1 - 6) were then examined for their cytotoxic effects towards MCF-7, HL-60, and HeLa cancer cell lines, as well as their DPPH radical scavenging activity. The results indicated that compound 4 possessed the strongest inhibitory effect toward HeLa cell line with IC50 value of 5.38 ± 0.92 μM. Compound 3 possessed selective cytotoxic activity on HL-60 cells with IC50 value of 6.27 ± 0.17 μM, compound 5 was found as the best in inhibiting proliferation with IC50 value of 2.25 ± 0.09 μM, and the other compounds showed significant inhibition with IC50 values ranging from 6.10 to 11.27 μM. Compound 5 also displayed the strongest cytotoxic effect toward MCF-7 cell line (IC50 4.32 ± 0.15 μM). Both 5 and 6 demonstrated strong radical scavenging activity (IC50 6.87 ± 0.03 and 4.33 ± 0.22 μM, respectively). Compounds 1 and 5 were isolated for the first time from this plant.
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KEYWORD
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Aruncus dioicus var. kamtschaticus, Cyanogenic glycosides, Monoterpenes, Caffeoyl glucoside
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