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KMID : 0620720150210010049
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Natural Product Sciences
2015 Volume.21 No. 1 p.49 ~ p.53
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Anti-Helicobacter pylori Compounds from Maackia amurensis
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Park Woo-Sung
Bae Ji-Yeong
Kim Hye-Jin
Kim Min-Gab
Ahn Mi-Jeong
Lee Woo-Kon
Kang Hyung-Lyun
Baik Seung-Chul
Lim Kyung-Mook
Lee Mi-Kyeong
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Abstract
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Eight isoflavonoid compounds were isolated from the EtOAc fraction of Maackia amurensis which had shown the highest anti-Helicobacter pylori activity among the fractions, using medium pressure liquid chromatography and recrystallization. Based on the spectroscopic data including 1H-NMR, 13C-NMR, HMBC and MS data, the chemical structures of the isolates were determined to be (-)-medicarpin (1), afromosin (2), formononetin (3), tectorigenin (4), prunetin (5), wistin (6), tectoridin (7) and ononin (8). Anti-H. pylori activity of each compound was evaluated with broth dilution assay. As a result, (-)-medicarpin (1), tectorigenin (4) and wistin (6) showed anti-H. pylori activity. (-)-Medicarpin (1) exhibited the most potent growth inhibitory activity against H. pylori with the minimal inhibitory concentration (MIC)90 of 25 μM, and tectorigenin (4) with MIC90 of 100 μM ranked the second. This is the first study to show the anti-H. pylori activity of M. amurensis, and it is suggested that the stem bark of M. amurensis or the EtOAc fraction or the isolated compounds can be a new natural source for the treatment of H. pylori infection.
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KEYWORD
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Maackia amurensis, Anti-Helicobacter pylori activity, (-)-Medicarpin, Tectorigenin
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