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KMID : 0620720150210020098
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Natural Product Sciences
2015 Volume.21 No. 2 p.98 ~ p.103
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Effect of the Mixture of Pueraria lobata and Sorbus commixta Extract on the Alcohol-induced Hangover in Rats
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Hong Se-Chul
Yoo Ji-Hyun
Oh Myeong-Hwan
Lee Hwan
Park Young-Sik
Shanmugam Parthasarathi
Park Jong-Dae
Pyo Mi-Kyung
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Abstract
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Pueraiae Radix (PR), Pueratia Folium (PF) and Sorbus commixta (SC) mixture, namely GS-SP (PR (1)/PF (2)/SC (0.5): v/v/v) was developed as hangover-relieving elixir and its effects on alcoholic metabolism have been investigated. The enzymatic activity of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) of GS-SP was shown higher than those of single treatment with PR, PL, SC, and the positive control group (YM-808). The survival rate of mouse liver cell line NCTC clone 1469 in the presence of acetaldehyde was 30.6, 22.2, and 8.7% at the GS-SP dosage level of 50, 100, and 200 μg/mL respectively. Different concentrations of 50, 100 and 200 mg/kg of GS-SP showed efficient activity for ADH and ALDH than YM-808 in rat fed with 25% ethanol. The levels of blood alcohol and acetaldehyde after oral administration of 200 mg/kg of GS-SP showed efficient activity of 11.7% and 37% than those of YM-808. These results have been supported to the potential for GS-SP to serve as an excellent potential in providing hangover relief and liver protection.
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KEYWORD
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Pueraiae lobata, Sorbus commixta, Alcohol dehydrogenase, Acetaldehyde dehydrogenase, Hangover
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