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KMID : 0620720150210030196
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Natural Product Sciences
2015 Volume.21 No. 3 p.196 ~ p.204
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Chemical Constituents from Leaves of Acanthopanax henryi (2)
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Zhi Li
Xiao Jun Li
Xiang Wang
Xiang Qian Liu
Kwon Ok-Kyoung
Qin Peng Zou
Lee Hyeong-Kyu
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Abstract
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Nineteen compounds, including one organic acid (1), one anthraquinone (2), one amide (3), and sixteen triterpenoid saponins (4 - 19) were isolated from the leaves of Acanthopanax henryi (Oliv.) Harms (Araliaceae). Their structures were determined on the basis of physicochemical properties and spectral analyses (HR-MS and NMR). Among them, compounds 2, 3, 7, 12 and 19 were new within Araliaceae. Compounds 4, 5, 9 - 11, 13, 14, 16 and 18 were reported for the first time from the Acanthopanax genus. Except for compounds 4 and 9, other compounds were isolated from A. henryi (Oliv.) Harms for the first time. The rare anthraquinone, compound 2, significantly decreased the production of NO and the levels of other inflammatory factors, such as TNF-α and IL-6, in lipopolysaccharide (LPS)-stimulated macrophages in a dose-dependent manner. This is the first time to report anti-inflammatory effect of this compound.
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KEYWORD
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Araliaceae, Acanthopanax henryi, Triterpenoid saponins, Anthraquinone, Nitric oxide, Anti-inflammatory
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