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KMID : 0620720150210030205
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Natural Product Sciences
2015 Volume.21 No. 3 p.205 ~ p.209
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Anti-inflammatory Activity of Fucoidan with Blocking NF-kB and STAT1 in Human Keratinocytes Cells
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Ryu Min-Ju
Chung Ha-Sook
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Abstract
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Fucoidan, a sulfated polysaccharide is found in several types of edible brown algae. It has shown numerous biological activities; however, the molecular mechanisms on the activity against atopic dermatitis have not been reported yet. We now examined the effects of fucoidan on chemokine production co-induced by TNF-α/ IFN-γ, and the possible mechanisms underlying these biological effects. Our data showed that fucoidan inhibited the TNF-α/IFN-γ-induced production of thymus and activation-regulated chemokine (TARC) and macrophagederived chemokine (MDC) mRNA in human keratinocytes HaCaT cells. Also, fucoidan suppressed phosphorylation of nuclear factor kappa B (NF-kB) and activation of signal transducer and activator of transcription (STAT)1 in a dose-dependent manner. In addition, fucoidan significantly inhibited activation of extracellular-signal-regulated kinases (ERK) phosphorylation. These data indicate that fucoidan shows anti-inflammatory effects by suppressing the expression of TNF-α/IFN-γ-induced chemokines by blocking NF-kB, STAT1, and ERK1/2 activation, suggestive of as used as a therapeutic application in inflammatory skin diseases, such as atopic dermatitis.
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KEYWORD
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Fucoidan, Anti-inflammation, Chemokine, Nuclear factor-kappa B, Signal transducer and activator of transcription
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