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KMID : 0620720150210040227
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Natural Product Sciences
2015 Volume.21 No. 4 p.227 ~ p.230
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Pestalotiolide A, a New Antiviral Phthalide Derivative from a Soft Coral-derived Fungus Pestalotiopsis sp
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Yan-Lai Jia
Fei-Fei Guan
Jie Ma
Wang Chang-Yun
Chang-Lun Shao
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Abstract
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Chemical investigation of the fermentation broth of a Soft Coral-Derived fungus Pestalotiopsis sp., led to the isolation of a new phthalide derivative, pestalotiolide A (1), three known analogues (2, 3 and 4), along with 5``-O-acetyl uridine (5) first isolated as a natural product. The structure of the new compound (1) was established by comprehensive spectroscopic analysis and chemical methods. Compounds 1 - 4 possessed varying degrees of antiviral activities, which was reported for the first time. Compared to the positive control ribavirin (IC50 = 418.0 μM), pestalotiolide A (1) exhibited significant anti-EV71 activity in vitro, with an IC50 value of 27.7 μM. Furthermore, the preliminary structure-activity relationship of antiviral activities was also discussed.
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KEYWORD
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Marine Fungus, Pestalotiopsis sp, Structure-Activity Relationship, Antiviral Activity
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