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KMID : 0620720150210040251
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Natural Product Sciences
2015 Volume.21 No. 4 p.251 ~ p.254
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Anti-Inflammatory Effect of Violapyrones B and C from a Marine-derived Streptomyces sp
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Lee Hwa-Sun
Lee Hyi-Seung
Lee Yeon-Ju
Lee Jong-Seok
Shin Hee-Jae
An Bong-Jeun
Kim Hyeon-Jeong
Cho Yong-Hun
Kim Dong-In
Jang Jae-Yoon
Kwak Jae-Hoon
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Abstract
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Recently, we reported violapyrones B, C, H and I, unusual 3, 4, 6-trisubstituted α-pyrone derivatives, from the culture broth of the marine Streptomyces sp. 112CH148. In previous studies, violapyrones have been shown to have antibacterial and antitumor activities. However, the anti-inflammatory effect of violapyrones has not been reported yet. As part of our ongoing study for the discovery of bioactive metabolites from marine microorganisms, we found that violapyrones also have anti-inflammatory activity. In this study, we investigated the effect of violapyrones on LPS-induced inflammatory responses in vitro. Violapyrones B and C did not affect the viability of RAW 264.7 cells at concentrations up to 25 μM. However, violapyrones B and C inhibited the production of NO compared to the LPS-induced control. In addition, violapyrones B and C down-regulated the expression of iNOS protein in LPS-stimulated RAW 264.7 cells. To the best of our knowledge, this is the first report on the anti-inflammatory activity of violapyrones B and C.
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KEYWORD
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Violapyrones, α-Pyrones, Streptomyces sp., Anti-inflammatory
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