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KMID : 0620720150210040289
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Natural Product Sciences
2015 Volume.21 No. 4 p.289 ~ p.292
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Two New Scalaranes from a Korean Marine Sponge Spongia sp
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Yang In-Ho
Kang Heon-Joong
Nam Sang-Jip
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Abstract
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Intensive chemical investigation of Korean marine sponge Spongia sp. has led to the isolation of two new scalaranes. The planar structures of the new compounds 1 and 2 were determined through 1D and 2D NMR spectral data analysis, while the relative stereochemistry of the compounds was determined based on the analysis of 1H-1H coupling constants and NOESY spectroscopic data. Compounds 1 and 2 did not display any significant biological activities on farnesoid X-activated receptor (FXR) in co-transfection assay.
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KEYWORD
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Scalarane, Sesterpenoid, Spongia sp, Korean sponge, Marine natural product
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