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KMID : 0620720160220010035
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Natural Product Sciences
2016 Volume.22 No. 1 p.35 ~ p.40
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Chemical Composition of Clausena lansium (Lour.) Skeels Leaves and Antifungal Activity
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Vu Duc Nam
Nguyen Minh Khoi
Le Viet Dung
Do Thi Ha
Fujimatsu Teruhisa
Takigawa Hirofumi
Kusuoku Hiroshi
Hashimoto Hiroshi
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Abstract
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The first study on chemical constituents and biological activities of Clausena lansium (Lour.) Skeels (Rutaceae) growing in Vietnam has been done. Phytochemical investigation of n-hexane extract led to the isolation of five compounds: dihydroindicolactone (1), 8-geranyloxy psoralen (2), imperatorin (3), heraclenol (4) and indicolactone (5), in which this is the first report on the presence of dihydroindicolactone (1). Their structures were elucidated based on LC/MS/NMR hyphenated techniques as well as comparison with those of literature data. The n-hexane extract and its subfractions, ethanol 95% extract and several isolated compounds were evaluated for antifungal activity.
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KEYWORD
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Antifungal, Clausena lansium, Dihydroindicolactone, Furanocoumarin
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