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KMID : 0620720160220010046
Natural Product Sciences
2016 Volume.22 No. 1 p.46 ~ p.52
Ginsenoside Re Enriched Fraction (GS-F3K1) from Ginseng Berries Ameliorates Ethanol-Induced Erectile Dysfunction via Nitric Oxide-cGMP Pathway
Pyo Mi-Kyung

Oh Myeong-Hwan
Lee Hwan
Park Young-Sik
Kim Na-Young
Park So-Hee
Song Ji-Hye
Park Jong-Dae
Park Kwang-Hyun
Jung Se-Hee
Lee Bong-Gun
Won Beom-Young
Shin Ki-Young
Lee Hyung-Gun
Abstract
Erectile dysfunction (ED) is a highly prevalent disorder that affects millions of men and considered to be an early symptom of atherosclerosis and a precursor of various systemic vascular disorders. The aim of the present study was to prepare ginsenoside Re enriched fraction (GS-F3K1, ginsenoside Re 10%, w/w) from ginseng berries flesh and to investigate the enhanced activities of GS-F3K1 on alcohol-induced ED. GS-F3K1 was prepared by the continuous liquid and solid separating centrifugation and circulatory ultrafiltration from ginseng berries flesh. GS-F3K1 was administered for 5 weeks in ethanol-induced ED rat by oral administration of 20% ethanol. To investigate the effects of GS-F3K1 on ED model, the levels of nitrite expression, cyclic guanosine monophosphate (cGMP) and erectile response of the penile corpus cavernosum of rat were measured. The erectile response of the corpus cavernosum was restored after GS-F3K1 administration, to a level similar to the normal group. The level of nitrite and cGMP expression in the corpus cavernosum of GS-F3K1-administered male rats was increased significantly compared to positive control group. GS-F3K1 from ginseng berries should effectively restore ethanol-induced ED in male rats and could be developed as a new functional food for the elderly men.
KEYWORD
GS-F3K1, Ginseng berry, Ethanol-induced erectile dysfunction, Nitrite, Cyclic guanosine monophosphate, Cgmp
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