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KMID : 0620720160220020082
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Natural Product Sciences
2016 Volume.22 No. 2 p.82 ~ p.86
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Compounds from a jellyfish-derived fungus Aspergillus fumigates
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Guan-yu Tao
Juan Liu
Yonghong Liu
Jung Jee-H.
Wei Guo
Xiao-qiong Wen
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Abstract
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Six compounds were isolated from the secondary metabolites of the jellyfish-derived fungus Aspergillus fumigates, whose structures were identified by chemical methods and spectroscopic analysis as pseurotin F1 (1), azaspirofurans B (2), (22E, 24R)-24-methyl-5α-cholesta-7,22-diene-3β,5,6β-triol (3), 5α,8α-epidioxyergosta- 6,22-dien-3β-o1 (4), cyclo-(L-Pro-L-Tyr) (5), fumitremorgin C (6). The compounds 1 - 5 were isolated from the fungus Aspergillus fumigates for the first time. The isolated compounds (1 - 6) were evaluated for antibiotic activity and cytotoxicity against six bacterial strains and ten human tumor cell lines, respectively.
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KEYWORD
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Nemopilema nomurai, Jellyfish-derived fungus, Aspergillus fumigates, Isolation, Structural elucidation
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