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KMID : 0620720160220020129
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Natural Product Sciences
2016 Volume.22 No. 2 p.129 ~ p.133
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Chemical Constituents from Buddleja officinalis and Their Inhibitory Effects on Nitric Oxide Production
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Park Tae-Wook
Lee Chul
Lee Jin-Woo
Jang Ha-Ri
Qinghao Jin
Lee Mi-Kyeong
Hwang Bang-Yeon
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Abstract
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Bioactivity-guided fractionation of a methanolic extract of Buddleja officinalis led to the isolation of two monoterpenes, crocusatin M (1), crocusatin C (2), a flavonoid, acacetin (3), three lignans, lariciresinol (4), pinoresinol (5), and syringaresinol (6), and two triterpenoidal saponins, mimengoside B (7) and songarosaponin A (8). The structures of isolates were identified based on 1D-, 2D-NMR, and MS data analysis. All isolates were tested for their inhibition on LPS-induced NO production in RAW 264.7 cells. As a result, mimengoside B (7) and songarosaponin A (8) showed a mild inhibitory activity of NO production.
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KEYWORD
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Buddleja officinalis, Buddlejaceae, NO production inhibitor
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