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KMID : 0620720160220020140
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Natural Product Sciences
2016 Volume.22 No. 2 p.140 ~ p.145
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Phenolic Constituents and Their Anti-inflammatory Activity from Echinochloa utilis Grains
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Duc Hung Nguyen
Bing Tian Zhao
Duc Dat Le
Woo Mi-Hee
Kim Ki-Yun
Kim Young-Ho
Ko Jee-Youn
Woo Koan-Sik
Yoon Young-Ho
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Abstract
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Seven phenolic compounds including p-coumaric acid (1), 4-hydroxybenzoic acid (2), 4-hydroxybenzaldehyde (3), vanillic acid (4), luteolin (5), acacetin (6), and tricin (7), were isolated from the methylene chloride and ethyl acetate fractions of Echinochloa utilis grains. Compounds (1 - 4, 6) were isolated for the first time from this plant. These compounds were tested for inhibitory activities against LPS-induced NO production in RAW 264.7 cells. Compounds 5 and 6 displayed significant inhibitory effects, with IC50 values of 27.9 ± 2.6 and 14.0 ± 1.1 μM, respectively. The results suggested that E. utilis ethanolic extract may be used as a potential source of anti-inflammatory agents and functional foods for the treatment of allergic diseases.
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KEYWORD
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Echinochloa utilis, Phenolic compounds, NO production
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