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KMID : 0620720160220030168
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Natural Product Sciences
2016 Volume.22 No. 3 p.168 ~ p.174
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Modulation of Melanin Synthesis by Amaranthus spp. L Seed Extract in Melan-a Cells
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Seo Jae-Ok
Do Moon-Ho
Hussain Mustatab Wahedi
Park Yong-Un
Kim Sun-Yeou
Lee Jae-Hak
Lee Taek-Hwan
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Abstract
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Anti-melanogenic effects of amaranth (AT), one of the key source of squalene, were investigated in melanocytes. Amaranth seed powder was extracted with water and melan-a cells were treated with various concentrations of AT. By using HPLC, content of myo-inositol, one of potential active components, was measured in the crude extract of AT.AT reduced the melanin content in melan-a melanocytes and down-regulated melanogenic enzyme activity such as tyrosinase, TRP-1 and TRP-2. By regulating melanogenic enzyme activity, AT may be a potential natural source for whitening agent. Myo-inositol was detected in AT by HPLC and may be one of the active compounds from AT involved in the regulation of anti-melanogenesis. In this study, we demonstrated that AT has anti-melanogenesis properties. This new function of amaranth may be useful in the development of new skin-whitening products and its value as food.
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KEYWORD
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Amaranth, Myo-inositol, Melan-a cells, Melanogenesis
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